Version 5.4
Homo sapiens Protein: NCAPH
Summary
InnateDB Protein IDBP-61716.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NCAPH
Protein Name non-SMC condensin I complex, subunit H
Synonyms BRRN1; CAP-H;
Species Homo sapiens
Ensembl Protein ENSP00000240423
InnateDB Gene IDBG-61714 (NCAPH)
Protein Structure
UniProt Annotation
Function Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. {ECO:0000269PubMed:11136719}.
Subcellular Localization Nucleus {ECO:0000269PubMed:11694586}. Cytoplasm {ECO:0000269PubMed:11694586}. Chromosome {ECO:0000269PubMed:11694586}. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDK1, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.
Disease Associations
Tissue Specificity Widely expressed at low level. Expressed in proliferating cells. {ECO:0000269PubMed:11694586}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 28 [view]
Protein-Protein 28 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000278 mitotic cell cycle
GO:0007076 mitotic chromosome condensation
Cellular Component
GO:0000796 condensin complex
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0015630 microtubule cytoskeleton
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR022816 Condensin complex subunit 2/barren
PFAM PF05786
PRINTS
PIRSF PIRSF017126
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q15003
PhosphoSite PhosphoSite-Q15003
TrEMBL E9PHA2
UniProt Splice Variant
Entrez Gene 23397
UniGene Hs.308045
RefSeq NP_056156
HUGO HGNC:1112
OMIM 602332
CCDS CCDS2021
HPRD 03820
IMGT
EMBL AC021188 AK303725 BC024211 D38553
GenPept AAH24211 BAA07556 BAG64701

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca