Version 5.4
| Homo sapiens Protein: ARHGEF26 | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-61959.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | ARHGEF26 | ||||||||
| Protein Name | Rho guanine nucleotide exchange factor (GEF) 26 | ||||||||
| Synonyms | CSGEF; HMFN1864; SGEF; | ||||||||
| Species | Homo sapiens | ||||||||
| Ensembl Protein | ENSP00000348828 | ||||||||
| InnateDB Gene | IDBG-61957 (ARHGEF26) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry. {ECO:0000269PubMed:15133129, ECO:0000269PubMed:17074883, ECO:0000269PubMed:17875742}. | ||||||||
| Subcellular Localization | Cell projection, ruffle {ECO:0000269PubMed:15133129, ECO:0000269PubMed:17875742}. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | Isoform 1 is broadly expressed, with highest levels in liver (at protein level). Certain mRNA species appear to be specifically expressed in prostate and liver. {ECO:0000269PubMed:12697679, ECO:0000269PubMed:15133129}. | ||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | |||||||||
| InterPro |
IPR000219
Dbl homology (DH) domain IPR001452 SH3 domain IPR001849 Pleckstrin homology domain IPR011511 Variant SH3 domain |
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| PFAM |
PF00621
PF00018 PF14604 PF00169 PF07653 |
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| PRINTS |
PR00452
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| PIRSF | |||||||||
| SMART |
SM00325
SM00326 SM00233 |
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| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | Q96DR7 | ||||||||
| PhosphoSite | PhosphoSite-Q96DR7 | ||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 26084 | ||||||||
| UniGene | Hs.608994 | ||||||||
| RefSeq | NP_001238891 | ||||||||
| HUGO | HGNC:24490 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS46938 | ||||||||
| HPRD | 11554 | ||||||||
| IMGT | |||||||||
| EMBL | AB073386 AC018452 AF415175 AF415176 AK022655 AK022884 AK123040 AL117429 AY552599 BC016628 BC078655 FJ695204 | ||||||||
| GenPept | AAH16628 AAH78655 AAL27001 AAL27002 AAS59842 BAB14159 BAB14292 BAD38637 BAG53860 CAB55918 | ||||||||