InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Psma2

Summary

InnateDB Protein

IDBP-619662.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Psma2

Protein Name

proteasome (prosome, macropain) subunit, alpha type 2

Synonyms

Lmpc3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000129767

InnateDB Gene

IDBG-131624 (Psma2)

Protein Structure

UniProt Annotation

Function

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. PSMA2 may have a potential regulatory effect on another component(s) of the proteasome complex through tyrosine phosphorylation. {ECO:0000269PubMed:22341445}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:22078707}. Nucleus {ECO:0000269PubMed:22078707}. Cytoplasm, P-body {ECO:0000269PubMed:22078707}. Note=Colocalizes with TRIM5 in the cytoplasmic bodies.

Disease Associations

Tissue Specificity

Detected in liver (at protein level). {ECO:0000269PubMed:22341445}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004175	endopeptidase activity
GO:0004298	threonine-type endopeptidase activity

Biological Process

GO:0006511	ubiquitin-dependent protein catabolic process
GO:0009615	response to virus
GO:0051603	proteolysis involved in cellular protein catabolic process

Cellular Component

GO:0000932	cytoplasmic mRNA processing body
GO:0005634	nucleus
GO:0005829	cytosol
GO:0005839	proteasome core complex
GO:0019773	proteasome core complex, alpha-subunit complex