Version 5.4
| Mus musculus Gene: Psma2 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-131624.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | Psma2 | ||||||||||||||||||
| Gene Name | proteasome (prosome, macropain) subunit, alpha type 2 | ||||||||||||||||||
| Synonyms | Lmpc3 | ||||||||||||||||||
| Species | Mus musculus | ||||||||||||||||||
| Ensembl Gene | ENSMUSG00000015671 | ||||||||||||||||||
| Encoded Proteins |
proteasome (prosome, macropain) subunit, alpha type 2
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000256646:
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 13:14613242-14625671 | ||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||
| Band | A1 | ||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
p53-Independent G1/S DNA damage checkpoint pathway
Autodegradation of the E3 ubiquitin ligase COP1 pathway
Apoptosis pathway
Signaling by the B Cell Receptor (BCR) pathway
Cell Cycle, Mitotic pathway
Class I MHC mediated antigen processing & presentation pathway
Disease pathway
Synthesis of DNA pathway
deletions in the AMER1 gene destabilize the destruction complex pathway
APC/C:Cdc20 mediated degradation of mitotic proteins pathway
Ubiquitin-dependent degradation of Cyclin D1 pathway
Signaling by Wnt pathway
CDT1 association with the CDC6:ORC:origin complex pathway
Separation of Sister Chromatids pathway
Hedgehog 'off' state pathway
DNA Replication pathway
Signaling by WNT in cancer pathway
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
Switching of origins to a post-replicative state pathway
degradation of DVL pathway
Cyclin A:Cdk2-associated events at S phase entry pathway
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins pathway
Degradation of beta-catenin by the destruction complex pathway
beta-catenin independent WNT signaling pathway
AUF1 (hnRNP D0) destabilizes mRNA pathway
p53-Independent DNA Damage Response pathway
p53-Dependent G1 DNA Damage Response pathway
p53-Dependent G1/S DNA damage checkpoint pathway
CDK-mediated phosphorylation and removal of Cdc6 pathway
AMER1 mutants destabilize the destruction complex pathway
Cell Cycle pathway
Stabilization of p53 pathway
Metabolism pathway
APC/C-mediated degradation of cell cycle proteins pathway
Immune System pathway
M Phase pathway
Cell Cycle Checkpoints pathway
SCF-beta-TrCP mediated degradation of Emi1 pathway
Hedgehog ligand biogenesis pathway
AXIN mutants destabilize the destruction complex, activating WNT signaling pathway
ER-Phagosome pathway pathway
T41 mutants of beta-catenin aren't phosphorylated pathway
Processing-defective Hh variants abrogate ligand secretion pathway
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A pathway
APC truncation mutants have impaired AXIN binding pathway
Antigen processing: Ubiquitination & Proteasome degradation pathway
Cross-presentation of soluble exogenous antigens (endosomes) pathway
Regulation of DNA replication pathway
Metabolism of amino acids and derivatives pathway
Orc1 removal from chromatin pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
M/G1 Transition pathway
PCP/CE pathway pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
Regulation of Apoptosis pathway
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex pathway
Regulation of APC/C activators between G1/S and early anaphase pathway
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 pathway
Autodegradation of Cdh1 by Cdh1:APC/C pathway
Activation of NF-kappaB in B cells pathway
Degradation of GLI2 by the proteasome pathway
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling pathway
Regulation of mitotic cell cycle pathway
APC/C:Cdc20 mediated degradation of Securin pathway
G1/S DNA Damage Checkpoints pathway
Degradation of GLI1 by the proteasome pathway
S37 mutants of beta-catenin aren't phosphorylated pathway
Hh ligand biogenesis disease pathway
AXIN missense mutants destabilize the destruction complex pathway
TCF dependent signaling in response to WNT pathway
GLI3 is processed to GLI3R by the proteasome pathway
Mitotic Metaphase and Anaphase pathway
G1/S Transition pathway
Removal of licensing factors from origins pathway
APC truncation mutants are not K63 polyubiquitinated pathway
Regulation of ornithine decarboxylase (ODC) pathway
Antigen processing-Cross presentation pathway
S45 mutants of beta-catenin aren't phosphorylated pathway
Mitotic G1-G1/S phases pathway
misspliced GSK3beta mutants stabilize beta-catenin pathway
TCF7L2 mutants don't bind CTBP pathway
Regulation of activated PAK-2p34 by proteasome mediated degradation pathway
Gene Expression pathway
Adaptive Immune System pathway
truncations of AMER1 destabilize the destruction complex pathway
Ubiquitin-dependent degradation of Cyclin D pathway
Signaling by Hedgehog pathway
degradation of AXIN pathway
Asymmetric localization of PCP proteins pathway
Cyclin E associated events during G1/S transition pathway
Signal Transduction pathway
truncated APC mutants destabilize the destruction complex pathway
SCF(Skp2)-mediated degradation of p27/p21 pathway
DNA Replication Pre-Initiation pathway
S33 mutants of beta-catenin aren't phosphorylated pathway
Mitotic Anaphase pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
Assembly of the pre-replicative complex pathway
S Phase pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
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| KEGG |
Proteasome pathway
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| INOH |
TGF-beta signaling pathway
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| PID NCI | |||||||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME | |||||||||||||||||||
| KEGG |
Proteasome pathway
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| INOH | |||||||||||||||||||
| PID NCI | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | P49722 | ||||||||||||||||||
| TrEMBL | Q8BKE0 | ||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 19166 | ||||||||||||||||||
| UniGene | Mm.429320 | ||||||||||||||||||
| RefSeq | NM_008944 | ||||||||||||||||||
| OMIM | |||||||||||||||||||
| CCDS | CCDS36602 | ||||||||||||||||||
| HPRD | |||||||||||||||||||
| IMGT | |||||||||||||||||||
| MGI ID | MGI:104885 | ||||||||||||||||||
| MGI Symbol | Psma2 | ||||||||||||||||||
| EMBL | AC092710 AF099733 AK012119 AK035578 AK053472 AK151883 AK152862 AK154011 AK167752 BC026768 CH466561 X70303 | ||||||||||||||||||
| GenPept | AAD50623 AAH26768 BAB28045 BAC29110 BAC35395 BAE30769 BAE31553 BAE32314 BAE39787 CAA49782 EDL32738 | ||||||||||||||||||
| RNA Seq Atlas | 19166 | ||||||||||||||||||