InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gstp1

Summary

InnateDB Protein

IDBP-619802.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gstp1

Protein Name

glutathione S-transferase, pi 1

Synonyms

GstpiB;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000129565

InnateDB Gene

IDBG-128794 (Gstp1)

Protein Structure

UniProt Annotation

Function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Can metabolize 1-chloro-2,4-dinitrobenzene. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Mitochondrion {ECO:0000250}. Nucleus {ECO:0000250}. Note=The 83 N-terminal amino acids function as un uncleaved transit peptide, and arginine residues within it are crucial for mitochondrial localization. {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitously expressed.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	29 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004364	glutathione transferase activity
GO:0005515	protein binding
GO:0008144	drug binding
GO:0008432	JUN kinase binding
GO:0019207	kinase regulator activity

Biological Process

GO:0000302	response to reactive oxygen species
GO:0002674	negative regulation of acute inflammatory response
GO:0006749	glutathione metabolic process
GO:0006805	xenobiotic metabolic process
GO:0009636	response to toxic substance
GO:0009890	negative regulation of biosynthetic process
GO:0014003	oligodendrocyte development
GO:0031100	organ regeneration
GO:0031667	response to nutrient levels
GO:0032355	response to estradiol
GO:0032691	negative regulation of interleukin-1 beta production
GO:0032720	negative regulation of tumor necrosis factor production
GO:0032869	cellular response to insulin stimulus
GO:0032872	regulation of stress-activated MAPK cascade
GO:0032873	negative regulation of stress-activated MAPK cascade
GO:0032930	positive regulation of superoxide anion generation
GO:0033591	response to L-ascorbic acid
GO:0035726	common myeloid progenitor cell proliferation
GO:0043066	negative regulation of apoptotic process
GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043200	response to amino acid
GO:0043407	negative regulation of MAP kinase activity
GO:0043508	negative regulation of JUN kinase activity
GO:0045471	response to ethanol
GO:0048147	negative regulation of fibroblast proliferation
GO:0051771	negative regulation of nitric-oxide synthase biosynthetic process
GO:0070372	regulation of ERK1 and ERK2 cascade
GO:0070373	negative regulation of ERK1 and ERK2 cascade
GO:0070664	negative regulation of leukocyte proliferation
GO:0071222	cellular response to lipopolysaccharide
GO:0071364	cellular response to epidermal growth factor stimulus
GO:0071385	cellular response to glucocorticoid stimulus
GO:0071460	cellular response to cell-matrix adhesion
GO:0071638	negative regulation of monocyte chemotactic protein-1 production
GO:2000429	negative regulation of neutrophil aggregation
GO:2000469	negative regulation of peroxidase activity
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0043234	protein complex

Protein Structure and Domains

PDB ID

MGI:95865

InterPro

IPR003082 Glutathione S-transferase, Pi class
IPR004045 Glutathione S-transferase, N-terminal
IPR004046 Glutathione S-transferase, C-terminal
IPR010987 Glutathione S-transferase, C-terminal-like
IPR012336 Thioredoxin-like fold

PFAM