InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Gstp1

Summary

InnateDB Gene

IDBG-128794.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gstp1

Gene Name

glutathione S-transferase, pi 1

Synonyms

GstpiB

Species

Mus musculus

Ensembl Gene

ENSMUSG00000060803

Encoded Proteins

IDBP-619802

glutathione S-transferase, pi 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 18962899

[Homo sapiens] GSTP1 suppresses LPS (lipopolysaccharide)-induced excessive production of pro-inflammatory factors by inhibiting LPS-stimulated MAPKs (mitogen-activated protein kinases) as well as NF-kappaB activation.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000084207:
Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. This GST family member is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:4035407-4037921

Strand

Reverse strand

Band

Transcripts

ENSMUST00000169613

ENSMUSP00000129565

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	29 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004364	glutathione transferase activity
GO:0005515	protein binding
GO:0008144	drug binding
GO:0008432	JUN kinase binding
GO:0019207	kinase regulator activity

Biological Process

GO:0000302	response to reactive oxygen species
GO:0002674	negative regulation of acute inflammatory response
GO:0006749	glutathione metabolic process
GO:0006805	xenobiotic metabolic process
GO:0009636	response to toxic substance
GO:0009890	negative regulation of biosynthetic process
GO:0014003	oligodendrocyte development
GO:0031100	organ regeneration
GO:0031667	response to nutrient levels
GO:0032355	response to estradiol
GO:0032691	negative regulation of interleukin-1 beta production
GO:0032720	negative regulation of tumor necrosis factor production
GO:0032869	cellular response to insulin stimulus
GO:0032872	regulation of stress-activated MAPK cascade
GO:0032873	negative regulation of stress-activated MAPK cascade
GO:0032930	positive regulation of superoxide anion generation
GO:0033591	response to L-ascorbic acid
GO:0035726	common myeloid progenitor cell proliferation
GO:0043066	negative regulation of apoptotic process
GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043200	response to amino acid
GO:0043407	negative regulation of MAP kinase activity
GO:0043508	negative regulation of JUN kinase activity
GO:0045471	response to ethanol
GO:0048147	negative regulation of fibroblast proliferation
GO:0051771	negative regulation of nitric-oxide synthase biosynthetic process
GO:0070372	regulation of ERK1 and ERK2 cascade
GO:0070373	negative regulation of ERK1 and ERK2 cascade
GO:0070664	negative regulation of leukocyte proliferation
GO:0071222	cellular response to lipopolysaccharide
GO:0071364	cellular response to epidermal growth factor stimulus
GO:0071385	cellular response to glucocorticoid stimulus
GO:0071460	cellular response to cell-matrix adhesion
GO:0071638	negative regulation of monocyte chemotactic protein-1 production
GO:2000429	negative regulation of neutrophil aggregation
GO:2000469	negative regulation of peroxidase activity
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway