Mus musculus Protein: St5 | |||||||
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Summary | |||||||
InnateDB Protein | IDBP-619964.2 | ||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||
Gene Symbol | St5 | ||||||
Protein Name | suppression of tumorigenicity 5 | ||||||
Synonyms | 2010004M01Rik; 2610305K15Rik; | ||||||
Species | Mus musculus | ||||||
Ensembl Protein | ENSMUSP00000130119 | ||||||
InnateDB Gene | IDBG-206177 (St5) | ||||||
Protein Structure | |||||||
UniProt Annotation | |||||||
Function | Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP- bound form. May be involved in cytoskeletal organization and tumorogenicity. Isoform 1 seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Isoform 3 may block ERK2 activation stimulated by ABL1. Isoform 3 may alter cell morphology and cell growth (By similarity). {ECO:0000250}. | ||||||
Subcellular Localization | |||||||
Disease Associations | |||||||
Tissue Specificity | |||||||
Comments | |||||||
Interactions | |||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
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Gene Ontology | |||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||
PDB ID | MGI:108517 | ||||||
InterPro |
IPR001194
DENN domain IPR005112 dDENN domain IPR005113 uDENN domain |
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PFAM |
PF02141
PF03455 PF03456 |
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PRINTS | |||||||
PIRSF | |||||||
SMART |
SM00799
SM00801 SM00800 |
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TIGRFAMs | |||||||
Post-translational Modifications | |||||||
Modification | |||||||
Cross-References | |||||||
SwissProt | Q924W7 | ||||||
PhosphoSite | PhosphoSite-Q924W7 | ||||||
TrEMBL | |||||||
UniProt Splice Variant | |||||||
Entrez Gene | 76954 | ||||||
UniGene | Mm.407522 | ||||||
RefSeq | NP_084087 | ||||||
MGI ID | |||||||
MGI Symbol | St5 | ||||||
OMIM | |||||||
CCDS | CCDS21735 | ||||||
HPRD | |||||||
IMGT | |||||||
EMBL | AJ307670 BC030391 BC032266 BC051034 | ||||||
GenPept | AAH30391 AAH32266 AAH51034 CAC38111 CAC38112 | ||||||