InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fga

Summary

InnateDB Protein

IDBP-619968.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fga

Protein Name

fibrinogen alpha chain

Synonyms

ENSMUSG00000059807; Fib;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000133117

InnateDB Gene

IDBG-154534 (Fga)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005198	structural molecule activity
GO:0005515	protein binding
GO:0030674	protein binding, bridging
GO:0050839	cell adhesion molecule binding

Biological Process

GO:0007160	cell-matrix adhesion
GO:0007165	signal transduction
GO:0007596	blood coagulation
GO:0030168	platelet activation
GO:0034116	positive regulation of heterotypic cell-cell adhesion
GO:0043623	cellular protein complex assembly
GO:0045907	positive regulation of vasoconstriction
GO:0045921	positive regulation of exocytosis
GO:0050714	positive regulation of protein secretion
GO:0051258	protein polymerization
GO:0051592	response to calcium ion
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0070527	platelet aggregation
GO:0072377	blood coagulation, common pathway
GO:0090277	positive regulation of peptide hormone secretion
GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2000352	negative regulation of endothelial cell apoptotic process

Cellular Component

GO:0005577	fibrinogen complex
GO:0005615	extracellular space
GO:0005938	cell cortex
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0031091	platelet alpha granule
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle

Protein Structure and Domains

PDB ID

MGI:1316726

InterPro

IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
IPR012290 Fibrinogen, alpha/beta/gamma chain, coiled coil domain
IPR021996 Fibrinogen alpha C domain

PFAM

PF00147
PF08702
PF12160

PRINTS

PIRSF

SMART

SM00186

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite