Version 5.4
Mus musculus Protein: Eci2
Summary
InnateDB Protein IDBP-620094.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Eci2
Protein Name enoyl-Coenzyme A delta isomerase 2
Synonyms Acbd2; Drs1; Hca88; Peci;
Species Mus musculus
Ensembl Protein ENSMUSP00000131735
InnateDB Gene IDBG-144727 (Eci2)
Protein Structure
UniProt Annotation
Function Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species. Has a preference for 3-trans substrates (By similarity). {ECO:0000250}.
Subcellular Localization Isoform 1: Mitochondrion {ECO:0000250}.Isoform 2: Peroxisome matrix {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000062 fatty-acyl-CoA binding
GO:0003824 catalytic activity
GO:0004165 dodecenoyl-CoA delta-isomerase activity
GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds
Biological Process
GO:0006635 fatty acid beta-oxidation
GO:0008152 metabolic process
GO:0009062 fatty acid catabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005777 peroxisome
GO:0005782 peroxisomal matrix
Protein Structure and Domains
PDB ID MGI:1346064
InterPro IPR000582 Acyl-CoA-binding protein, ACBP
IPR001753 Crotonase superfamily
IPR029045 ClpP/crotonase-like domain
PFAM PF00887
PF00378
PRINTS PR00689
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9WUR2
PhosphoSite PhosphoSite-Q9WUR2
TrEMBL E9Q858
UniProt Splice Variant
Entrez Gene 23986
UniGene Mm.28883
RefSeq NP_001103801
MGI ID
MGI Symbol Eci2
OMIM
CCDS CCDS49234
HPRD
IMGT
EMBL AC124537 AF153613 AK009478 BC001983
GenPept AAD34174 AAH01983 BAB26315

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca