InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ang

Summary

InnateDB Protein

IDBP-620105.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ang

Protein Name

angiogenin, ribonuclease, RNase A family, 5

Synonyms

AI385586; Ang1; Rnase5; Rnase5a;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000132084

InnateDB Gene

IDBG-157169 (Ang)

Protein Structure

UniProt Annotation

Function

Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Note=Rapidly endocytosed by target cells and translocated to the nucleus where it accumulates in the nucleolus and binds to DNA. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003723	RNA binding
GO:0003779	actin binding
GO:0004540	ribonuclease activity
GO:0005102	receptor binding
GO:0005507	copper ion binding
GO:0008201	heparin binding
GO:0016892	endoribonuclease activity, producing 3'-phosphomonoesters

Biological Process

GO:0001525	angiogenesis
GO:0001666	response to hypoxia
GO:0001938	positive regulation of endothelial cell proliferation
GO:0006651	diacylglycerol biosynthetic process
GO:0007202	activation of phospholipase C activity
GO:0007417	central nervous system development
GO:0009303	rRNA transcription
GO:0017148	negative regulation of translation
GO:0030041	actin filament polymerization
GO:0030154	cell differentiation
GO:0032431	activation of phospholipase A2 activity
GO:0048662	negative regulation of smooth muscle cell proliferation
GO:0050714	positive regulation of protein secretion
GO:0090501	RNA phosphodiester bond hydrolysis
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic

Cellular Component

GO:0005576	extracellular region
GO:0005605	basal lamina
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0030426	growth cone
GO:0032311	angiogenin-PRI complex
GO:0043025	neuronal cell body