Version 5.4
Mus musculus Gene: Ang
Summary
InnateDB Gene IDBG-157169.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ang
Gene Name angiogenin, ribonuclease, RNase A family, 5
Synonyms AI385586; Ang1; Rnase5; Rnase5a
Species Mus musculus
Ensembl Gene ENSMUSG00000072115
Encoded Proteins
IDBP-157171
angiogenin, ribonuclease, RNase A family, 5
IDBP-620105
angiogenin, ribonuclease, RNase A family, 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the pancreatic ribonuclease A superfamily and is a potent inducer of neovascularization. The encoded protein is a secreted multifunctional tRNA-specific ribonuclease that promotes angiogenesis in response to angiogenetic stimuli such as hypoxia, mediates stress-induced translational repression by cleaving cellular tRNAs, stimulates cell proliferation by mediating rRNA transcription in prostate cancer cells, and is involved in neurite pathfinding. This gene resides in a cluster of highly related genes. It shares dual promoters and 5' exons with the ribonuclease, RNase A family 4 gene. Two alternatively spliced variants, with different 5' exons but the same coding exon, have been identified. Multiple pseudogenes have been found for this gene. [provided by RefSeq, Jun 2009]
This gene encodes a member of the pancreatic ribonuclease A superfamily and is a potent inducer of neovascularization. The encoded protein is a secreted multifunctional tRNA-specific ribonuclease that promotes angiogenesis in response to angiogenetic stimuli such as hypoxia, mediates stress-induced translational repression by cleaving cellular tRNAs, stimulates cell proliferation by mediating rRNA transcription in prostate cancer cells, and is involved in neurite pathfinding. This gene resides in a cluster of highly related genes. It shares dual promoters and 5\' exons with the ribonuclease, RNase A family 4 gene. Two alternatively spliced variants, with different 5\' exons but the same coding exon, have been identified. Multiple pseudogenes have been found for this gene. [provided by RefSeq, Jun 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:51091077-51102007
Strand Forward strand
Band C1
Transcripts
ENSMUST00000069011 ENSMUSP00000067434
ENSMUST00000171688 ENSMUSP00000132084
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0003779 actin binding
GO:0004540 ribonuclease activity
GO:0005102 receptor binding
GO:0005507 copper ion binding
GO:0008201 heparin binding
GO:0016892 endoribonuclease activity, producing 3'-phosphomonoesters
Biological Process
GO:0001525 angiogenesis
GO:0001666 response to hypoxia
GO:0001938 positive regulation of endothelial cell proliferation
GO:0006651 diacylglycerol biosynthetic process
GO:0007202 activation of phospholipase C activity
GO:0007417 central nervous system development
GO:0009303 rRNA transcription
GO:0017148 negative regulation of translation
GO:0030041 actin filament polymerization
GO:0030154 cell differentiation
GO:0032431 activation of phospholipase A2 activity
GO:0048662 negative regulation of smooth muscle cell proliferation
GO:0050714 positive regulation of protein secretion
GO:0090501 RNA phosphodiester bond hydrolysis
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic
Cellular Component
GO:0005576 extracellular region
GO:0005605 basal lamina
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0030426 growth cone
GO:0032311 angiogenin-PRI complex
GO:0043025 neuronal cell body
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000214274
View Gene Order
Pathways
NETPATH
REACTOME
REACT_224553
Hemostasis pathway
REACT_225233
Cell surface interactions at the vascular wall pathway
REACT_211860
Tie2 Signaling pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001161731 NM_007447
OMIM
CCDS CCDS27034
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca