InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DHX36

Summary

InnateDB Protein

IDBP-62013.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DHX36

Protein Name

DEAH (Asp-Glu-Ala-His) box polypeptide 36

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000330113

InnateDB Gene

IDBG-62011 (DHX36)

Protein Structure

UniProt Annotation

Function

Proposed to have a global role in regulating mRNA expression including transcriptional regulation and mRNA stability. Binds with high affinity to and resolves tetramolecular RNA and DNA quadruplex structures. Unwinds intramolecular quadruplexes derived from the ZIC1 and the MYC promoters. Binds to quadruplex structures in the promoters of YY1 and ALPL genes and regulates their expression. Binds to telomerase RNA template component (TERC) 5'-end (nucleotides 1-43) and unwinds an internal quadruplex formation in TERC 5'-end to promote P1 helix formation; the P1 helix acts as a template boundary ensuring accurate reverse transcription and is disrupted by quadruplex formation. May be involved in regulation of telomere length. Plays a role in degradation and deadenylation of mRNAs containing in their 3'-UTR the consensus ARE sequence element. May function in sex development and spermatogenesis. May play a role in ossification. {ECO:0000269PubMed:12198572, ECO:0000269PubMed:14731398, ECO:0000269PubMed:16150737, ECO:0000269PubMed:18842585, ECO:0000269PubMed:20472641, ECO:0000269PubMed:21149580, ECO:0000269PubMed:21586581, ECO:0000269PubMed:21993297, ECO:0000269PubMed:22238380}.

Subcellular Localization

Nucleus. Cytoplasm. Chromosome, telomere {ECO:0000305}. Note=Isoform 1 preferentially localized to the nucleus and isoform 2 localized to the cytoplasm. However, partitioning of cellular localization between the nucleus and cytoplasm is not exclusive, as isoform 1 was also detected in the cytoplasm. Both isoforms were excluded from nucleoli. Localizes to cytoplasmic stress granules.

Disease Associations

Tissue Specificity

Highly expressed in testis. {ECO:0000269PubMed:12198572, ECO:0000269PubMed:14731398}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	37 [view]
Protein-Protein	37 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001047	core promoter binding
GO:0002151	G-quadruplex RNA binding
GO:0003676	nucleic acid binding
GO:0003725	double-stranded RNA binding
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008026	ATP-dependent helicase activity
GO:0008094	DNA-dependent ATPase activity
GO:0042826	histone deacetylase binding
GO:0044212	transcription regulatory region DNA binding
GO:0044822	poly(A) RNA binding
GO:0051880	G-quadruplex DNA binding

Biological Process

GO:0001503	ossification
GO:0006200	ATP catabolic process
GO:0006351	transcription, DNA-templated
GO:0010501	RNA secondary structure unwinding
GO:0032206	positive regulation of telomere maintenance
GO:0032481	positive regulation of type I interferon production
GO:0045087	innate immune response (InnateDB)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0000781	chromosome, telomeric region
GO:0005634	nucleus
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR001650 Helicase, C-terminal
IPR007502 Helicase-associated domain
IPR011545 DEAD/DEAH box helicase domain
IPR011709 Domain of unknown function DUF1605
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00271
PF04408
PF00270
PF07717

PRINTS

PIRSF

SMART

SM00490
SM00847
SM00487

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9H2U1