Homo sapiens Protein: LYPD6B
Summary
InnateDB Protein IDBP-620130.1
Last Modified 2018-06-05 [Report errors or provide feedback]
Gene Symbol LYPD6B
Protein Name LY6/PLAUR domain containing 6B
Synonyms CT116; LYPD7;
Species Homo sapiens
Ensembl Protein ENSP00000386479
InnateDB Gene IDBG-114464 (LYPD6B)
Protein Structure
UniProt Annotation
Function Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro acts on nAChRs in a subtype- and stoichiometry-dependent manner. Modulates specifically alpha-3(3):beta-4(2) nAChRs by enhancing the sensitivity to ACh, decreasing ACh-induced maximal current response and increasing the rate of desensitization to ACh; has no effect on alpha-7 homomeric nAChRs; modulates alpha-3(2):alpha- 5:beta-4(2) nAChRs in the context of CHRNA5/alpha-5 variant Asn- 398 but not its wild-type sequence. {ECO:0000269PubMed:26586467}.
Subcellular Localization Cell membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0030548 acetylcholine receptor regulator activity
Biological Process
GO:0006501 C-terminal protein lipidation
GO:0099601 regulation of neurotransmitter receptor activity
Cellular Component
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0031225 anchored component of membrane
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8NI32
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 130576
UniGene
RefSeq NP_001303935
HUGO HGNC:27018
OMIM
CCDS CCDS82519
HPRD
IMGT
EMBL AC009230 AC073271 AF435957 BC018203 BC040176 CH471058
GenPept AAH18203 AAH40176 AAM20908 AAY14974 EAX11541 EAX11542 EAX11543