Homo sapiens Protein: ATG9A
Summary
InnateDB Protein IDBP-620133.1
Last Modified 2018-06-05 [Report errors or provide feedback]
Gene Symbol ATG9A
Protein Name autophagy related 9A
Synonyms APG9L1; mATG9; MGD3208;
Species Homo sapiens
Ensembl Protein ENSP00000386482
InnateDB Gene IDBG-123104 (ATG9A)
Protein Structure
UniProt Annotation
Function Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Cycles between a juxta-nuclear trans-Golgi network compartment and late endosomes. Nutrient starvation induces accumulation on autophagosomes. Starvation-dependent trafficking requires ULK1, ATG13 and SUPT20H. {ECO:0000269PubMed:16940348}.
Subcellular Localization Cytoplasmic vesicle, autophagosome membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Under amino acid starvation or rapamycin treatment, redistributes from a juxtanuclear clustered pool to a dispersed peripheral cytosolic pool. The starvation- induced redistribution depends on ULK1, ATG13, as well as SH3GLB1.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 67 experimentally validated interaction(s) in this database.
Experimentally validated
Total 67 [view]
Protein-Protein 65 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000045 autophagosome assembly
GO:0000422 autophagy of mitochondrion
GO:0006914 autophagy
GO:0015031 protein transport
GO:0034497 protein localization to phagophore assembly site
GO:0044805 late nucleophagy
Cellular Component
GO:0000407 phagophore assembly site
GO:0005768 endosome
GO:0005770 late endosome
GO:0005776 autophagosome
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031410 cytoplasmic vesicle
GO:0031902 late endosome membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0055037 recycling endosome
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q7Z3C6
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 79065
UniGene
RefSeq
HUGO HGNC:22408
OMIM 612204
CCDS
HPRD
IMGT
EMBL AC068946 AK021732 AK025822 AK027448 AL833865 BC001098 BC021202 BC065534 BK004018 BX537984 BX538192 BX538198 CH471063
GenPept AAH01098 AAH21202 AAH65534 BAB13882 BAB15246 BAB55119 CAD38723 CAD97944 CAD98061 CAD98064 DAA05199 EAW70706