InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Prg4

Summary

InnateDB Protein

IDBP-620247.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Prg4

Protein Name

proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein)

Synonyms

CACP; DOL54; JCAP; lubricin; MSF; SZP;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000128943

InnateDB Gene

IDBG-197710 (Prg4)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005044	scavenger receptor activity
GO:0030247	polysaccharide binding

Biological Process

GO:0006898	receptor-mediated endocytosis
GO:0006955	immune response
GO:0018149	peptide cross-linking
GO:0042127	regulation of cell proliferation
GO:0045409	negative regulation of interleukin-6 biosynthetic process
GO:0071425	hematopoietic stem cell proliferation

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:1891344

InterPro

IPR000585 Hemopexin-like domain
IPR001212 Somatomedin B domain
IPR003302 Cornifin (SPRR1)
IPR018487 Hemopexin-like repeats
IPR020436 Somatomedin B, chordata

PFAM

PF01033
PF02389
PF00045

PRINTS

PR00022

PIRSF

SMART

SM00201
SM00120

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt