InnateDB Protein
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IDBP-620289.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Ndst4
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Protein Name
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N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
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Synonyms
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4930439H17Rik;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000133341
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InnateDB Gene
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IDBG-192456 (Ndst4)
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Protein Structure
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Function |
Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has low deacetylase activity but high sulfotransferase activity. {ECO:0000269PubMed:11087757}.
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Subcellular Localization |
Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed at low level in brain and throughout embryogenesis. Not expressed in other tissues. {ECO:0000269PubMed:11087757}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0015012
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heparan sulfate proteoglycan biosynthetic process
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GO:0030210
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heparin biosynthetic process
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Cellular Component |
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PDB ID |
MGI:1932545
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InterPro |
IPR000863
Sulfotransferase domain
IPR021930
Heparan sulphate-N-deacetylase
IPR027417
P-loop containing nucleoside triphosphate hydrolase
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PFAM |
PF00685
PF12062
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9EQW8
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
64580
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UniGene |
Mm.444289
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RefSeq |
NP_072087
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MGI ID |
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MGI Symbol |
Ndst4
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OMIM |
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CCDS |
CCDS17820
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HPRD |
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IMGT |
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EMBL |
AB036838
AC111141
AC140797
AC164153
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GenPept |
BAB18517
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