InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pik3c2a

Summary

InnateDB Protein

IDBP-620298.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pik3c2a

Protein Name

phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide

Synonyms

Cpk-m; PI3KC2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000126092

InnateDB Gene

IDBG-207422 (Pik3c2a)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016303	1-phosphatidylinositol-3-kinase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016773	phosphotransferase activity, alcohol group as acceptor
GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity
GO:0035091	phosphatidylinositol binding

Biological Process

GO:0006897	endocytosis
GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process
GO:0046854	phosphatidylinositol phosphorylation
GO:0048015	phosphatidylinositol-mediated signaling

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005942	phosphatidylinositol 3-kinase complex
GO:0016020	membrane
GO:0031982	vesicle
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1203729

InterPro

IPR000008 C2 domain
IPR000341 Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain
IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
IPR001263 Phosphoinositide 3-kinase, accessory (PIK) domain
IPR001683 Phox homologous domain
IPR002420 Phosphatidylinositol 3-kinase, C2 domain
IPR011009 Protein kinase-like domain
IPR016024 Armadillo-type fold
IPR029071 Ubiquitin-related domain

PFAM

PF00168
PF00794
PF00454
PF00613
PF00787
PF00792

PRINTS

PR00360

PIRSF

SMART

SM00239
SM00144
SM00146
SM00145
SM00312
SM00142

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt