InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Pik3c2a

Summary

InnateDB Gene

IDBG-207422.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pik3c2a

Gene Name

phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide

Synonyms

Cpk-m; PI3KC2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000030660

Encoded Proteins

IDBP-620298

phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000011405:
The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:116337276-116443458

Strand

Reverse strand

Band

Transcripts

ENSMUST00000170430

ENSMUSP00000126092

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016303	1-phosphatidylinositol-3-kinase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016773	phosphotransferase activity, alcohol group as acceptor
GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity
GO:0035091	phosphatidylinositol binding

Biological Process

GO:0006897	endocytosis
GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process
GO:0046854	phosphatidylinositol phosphorylation
GO:0048015	phosphatidylinositol-mediated signaling

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005942	phosphatidylinositol 3-kinase complex
GO:0016020	membrane
GO:0031982	vesicle
GO:0070062	extracellular vesicular exosome