InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Jarid2

Summary

InnateDB Protein

IDBP-620356.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Jarid2

Protein Name

jumonji, AT rich interactive domain 2

Synonyms

Jmj; jumonji;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000134675

InnateDB Gene

IDBG-147776 (Jarid2)

Protein Structure

UniProt Annotation

Function

Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis. Acts by modulating histone methyltransferase activity and promoting the recruitment of histone methyltransferase complexes to their target genes. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells. Does not have histone demethylase activity but regulates activity of various histone methyltransferase complexes. In embryonic stem cells, it associates with the PRC2 complex and inhibits trimethylation of 'Lys-27' of histone H3 (H3K27me3) by the PRC2 complex, thereby playing a key role in differentiation of embryonic stem cells and normal development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases. Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5. Participates in the negative regulation of cell proliferation signaling. {ECO:0000269PubMed:10807864, ECO:0000269PubMed:10913339, ECO:0000269PubMed:12852854, ECO:0000269PubMed:12890668, ECO:0000269PubMed:15542826, ECO:0000269PubMed:15870077, ECO:0000269PubMed:19010785, ECO:0000269PubMed:20064375, ECO:0000269PubMed:20064376, ECO:0000269PubMed:20075857}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00355, ECO:0000255PROSITE-ProRule:PRU00537, ECO:0000269PubMed:10807864, ECO:0000269PubMed:10913339, ECO:0000269PubMed:20064375, ECO:0000269PubMed:20064376}. Note=Colocalizes with the PRC2 complex on chromatin.

Disease Associations

Tissue Specificity

Widely expressed in embryos. In adults, expressed at high levels in heart, skeletal muscle, brain and thymus. {ECO:0000269PubMed:10807864}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	35 [view]
Protein-Protein	34 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0005515	protein binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001889	liver development
GO:0006351	transcription, DNA-templated
GO:0008285	negative regulation of cell proliferation
GO:0016568	chromatin modification
GO:0031061	negative regulation of histone methylation
GO:0042127	regulation of cell proliferation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0048536	spleen development
GO:0048538	thymus development
GO:0048863	stem cell differentiation
GO:0051574	positive regulation of histone H3-K9 methylation