Version 5.4
Mus musculus Protein: Rb1
Summary
InnateDB Protein IDBP-620479.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rb1
Protein Name retinoblastoma 1
Synonyms pRb; Rb; Rb-1;
Species Mus musculus
Ensembl Protein ENSMUSP00000125967
InnateDB Gene IDBG-179829 (Rb1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 59 experimentally validated interaction(s) in this database.
They are also associated with 228 interaction(s) predicted by orthology.
Experimentally validated
Total 59 [view]
Protein-Protein 59 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 228 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0007050 cell cycle arrest
GO:0008285 negative regulation of cell proliferation
GO:0030182 neuron differentiation
GO:0031175 neuron projection development
GO:0034349 glial cell apoptotic process
GO:0035914 skeletal muscle cell differentiation
GO:0042551 neuron maturation
GO:0043353 enucleate erythrocyte differentiation
GO:0045087 innate immune response (InnateDB)
GO:0045651 positive regulation of macrophage differentiation
GO:0045786 negative regulation of cell cycle
GO:0045879 negative regulation of smoothened signaling pathway
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048565 digestive tract development
GO:0048667 cell morphogenesis involved in neuron differentiation
GO:0050680 negative regulation of epithelial cell proliferation
GO:0051146 striated muscle cell differentiation
GO:0051301 cell division
GO:0051402 neuron apoptotic process
GO:0051726 regulation of cell cycle
GO:0097284 hepatocyte apoptotic process
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005819 spindle
Protein Structure and Domains
PDB ID MGI:97874
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL E9Q5C5
UniProt Splice Variant
Entrez Gene 19645
UniGene Mm.273862
RefSeq
MGI ID
MGI Symbol Rb1
OMIM
CCDS
HPRD
IMGT
EMBL AC154718 CT571265
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca