InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gtf2i

Summary

InnateDB Protein

IDBP-620508.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gtf2i

Protein Name

general transcription factor II I

Synonyms

6030441I21Rik; BAP-135; Diws1t; GtfII-I; Spin; TFII-I; WBSCR6;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000134440

InnateDB Gene

IDBG-202636 (Gtf2i)

Protein Structure

UniProt Annotation

Function

Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C- FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box (By similarity). Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B- lymphocyte activation. {ECO:0000250, ECO:0000269PubMed:16738337}.

Subcellular Localization

Cytoplasm. Nucleus. Note=Colocalizes with BTK in the cytoplasm. {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 62 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	62 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0051019	mitogen-activated protein kinase binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0014886	transition between slow and fast fiber
GO:0016525	negative regulation of angiogenesis
GO:0051481	negative regulation of cytosolic calcium ion concentration