Version 5.4
Mus musculus Protein: Sox21
Summary
InnateDB Protein IDBP-620578.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sox21
Protein Name SRY-box containing gene 21
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000127396
InnateDB Gene IDBG-186289 (Sox21)
Protein Structure
UniProt Annotation
Function May play a role as an activator of transcription of OPRM1. Overexpression of SOX21 can up-regulate the OPRM1 distal promoter activity in mor-expressing neuronal cells. {ECO:0000269PubMed:12446692}.
Subcellular Localization Nucleus {ECO:0000255PROSITE- ProRule:PRU00267}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
Biological Process
GO:0001942 hair follicle development
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0042633 hair cycle
GO:0043588 skin development
GO:0048863 stem cell differentiation
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:2654070
InterPro IPR000104 Antifreeze protein, type I
IPR009071 High mobility group box domain
IPR022097 Transcription factor SOX
PFAM PF00505
PF09011
PF12336
PRINTS PR00308
PIRSF
SMART SM00398
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q811W0
PhosphoSite PhosphoSite-Q811W0
TrEMBL
UniProt Splice Variant
Entrez Gene 223227
UniGene Mm.70950
RefSeq NP_808421
MGI ID
MGI Symbol Sox21
OMIM
CCDS CCDS27334
HPRD
IMGT
EMBL AY069926 AY142959 BC069176 BC147556 BC147565
GenPept AAH69176 AAI47557 AAI47566 AAL49967 AAN60055

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca