Version 5.4
Homo sapiens Protein: ANO2
Summary
InnateDB Protein IDBP-62059.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ANO2
Protein Name anoctamin 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000348453
InnateDB Gene IDBG-13438 (ANO2)
Protein Structure
UniProt Annotation
Function Calcium-activated chloride channel (CaCC) which may play a role in olfactory signal transduction. Odorant molecules bind to odor-sensing receptors (OSRs), leading to an increase in calcium entry that activates CaCC current which amplifies the depolarization of the OSR cells, ANO2 seems to be the underlying chloride channel involved in this process. May mediate light perception amplification in retina. {ECO:0000269PubMed:19474308, ECO:0000269PubMed:20056604, ECO:0000269PubMed:21890523, ECO:0000269PubMed:21984732}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:20056604}; Multi-pass membrane protein {ECO:0000269PubMed:20056604}.
Disease Associations
Tissue Specificity Retina, especially in the photoreceptor synaptic terminals. {ECO:0000269PubMed:19474308}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005229 intracellular calcium activated chloride channel activity
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006821 chloride transport
GO:0034220 ion transmembrane transport
GO:0055085 transmembrane transport
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005634 nucleus
GO:0005886 plasma membrane
GO:0031513 nonmotile primary cilium
GO:0034707 chloride channel complex
Protein Structure and Domains
PDB ID
InterPro IPR007632 Anoctamin
PFAM PF04547
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NQ90
PhosphoSite PhosphoSite-Q9NQ90
TrEMBL Q69YW4
UniProt Splice Variant
Entrez Gene 57101
UniGene
RefSeq NP_001265526
HUGO HGNC:1183
OMIM 610109
CCDS CCDS44807
HPRD 11634
IMGT
EMBL AC006431 AC006560 AC137627 AJ272204 AK024010 AL137419 FJ384095
GenPept ACL36050 BAB14773 CAC01125 CAH10704

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca