InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cd79b

Summary

InnateDB Protein

IDBP-620783.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cd79b

Protein Name

CD79B antigen

Synonyms

B29; Ig-beta; Igb; Igbeta;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000129029

InnateDB Gene

IDBG-213455 (Cd79b)

Protein Structure

UniProt Annotation

Function

Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation. {ECO:0000269PubMed:10352267, ECO:0000269PubMed:12356683, ECO:0000269PubMed:15661879, ECO:0000269PubMed:8175787}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:10587346, ECO:0000269PubMed:11238609, ECO:0000269PubMed:15661879}; Single- pass type I membrane protein {ECO:0000269PubMed:10587346, ECO:0000269PubMed:11238609, ECO:0000269PubMed:15661879}. Note=Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts.

Disease Associations

Tissue Specificity

B-cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0005515	protein binding

Biological Process

GO:0007166	cell surface receptor signaling pathway
GO:0050853	B cell receptor signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0019815	B cell receptor complex

Protein Structure and Domains

PDB ID

MGI:96431

InterPro

IPR003110 Phosphorylated immunoreceptor signalling ITAM
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin

PFAM

PF02189
PF07679
PF07686
PF00047

PRINTS

PIRSF

SMART

SM00077
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P15530