Version 5.4
Mus musculus Protein: Rgmb
Summary
InnateDB Protein IDBP-620805.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rgmb
Protein Name RGM domain family, member B
Synonyms 1110059F19Rik; DRAGON;
Species Mus musculus
Ensembl Protein ENSMUSP00000126177
InnateDB Gene IDBG-140416 (Rgmb)
Protein Structure
UniProt Annotation
Function Member of the repulsive guidance molecule (RGM) family that contributes to the patterning of the developing nervous system. Acts as a bone morphogenetic protein (BMP) coreceptor that potentiates BMP signaling. Promotes neuronal adhesion. May inhibit neurite outgrowth (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:15890774}; Lipid-anchor, GPI-anchor {ECO:0000269PubMed:15890774}. Membrane raft {ECO:0000269PubMed:15890774}.
Disease Associations
Tissue Specificity Detected in neonatal and adult dorsal root ganglion sensory neurons, spinal cord, and brain (at protein level). Also expressed at high levels in retinal ganglion cells of developing mouse, extending to the optic nerve (at protein level). Expressed in testis, epididymis, ovary, uterus, and pituitary. {ECO:0000269PubMed:14985445, ECO:0000269PubMed:15890774}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0042802 identical protein binding
Biological Process
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0030509 BMP signaling pathway
GO:0045087 innate immune response (InnateDB)
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
GO:0045121 membrane raft
GO:0046658 anchored component of plasma membrane
Protein Structure and Domains
PDB ID MGI:1916049
InterPro IPR009496 Repulsive guidance molecule, C-terminal
IPR010536 Repulsive guidance molecule, N-terminal
PFAM PF06534
PF06535
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q7TQ33
PhosphoSite PhosphoSite-Q7TQ33
TrEMBL
UniProt Splice Variant
Entrez Gene 68799
UniGene Mm.397987
RefSeq NP_848730
MGI ID
MGI Symbol Rgmb
OMIM
CCDS CCDS37455
HPRD
IMGT
EMBL AJ557514 AK035713 AK080819 BC096024 BC138890
GenPept AAH96024 AAI38891 BAC29163 BAC38034 CAD89719

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca