Version 5.4
| Mus musculus Gene: Rgmb | |||||||||||
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| Summary | |||||||||||
| InnateDB Gene | IDBG-140416.6 | ||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
| Gene Symbol | Rgmb | ||||||||||
| Gene Name | RGM domain family, member B | ||||||||||
| Synonyms | 1110059F19Rik; DRAGON | ||||||||||
| Species | Mus musculus | ||||||||||
| Ensembl Gene | ENSMUSG00000048027 | ||||||||||
| Encoded Proteins |
RGM domain family, member B
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||
| InnateDB Annotation | |||||||||||
| Summary |
Rgmb is highly expressed in macrophages and negatively regulates Il6 expression in a BMP ligand-dependent manner via MAPK and ERK pathway.
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| InnateDB Annotation from Orthologs | |||||||||||
| Summary |
[Homo sapiens] RGMB is highly expressed in macrophages and negatively regulates IL6 expression in a BMP ligand-dependent manner via MAPK and ERK pathway. (Demonstrated in murine model)
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| Entrez Gene | |||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000174136:
RGMB is a glycosylphosphatidylinositol (GPI)-anchored member of the repulsive guidance molecule family (see RGMA, MIM 607362) and contributes to the patterning of the developing nervous system (Samad et al., 2005 [PubMed 15671031]).[supplied by OMIM, Apr 2009] |
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| Gene Information | |||||||||||
| Type | Protein coding | ||||||||||
| Genomic Location | Chromosome 17:15806253-15826586 | ||||||||||
| Strand | Reverse strand | ||||||||||
| Band | A2 | ||||||||||
| Transcripts |
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| Interactions | |||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||
| NETPATH | |||||||||||
| REACTOME |
Netrin-1 signaling pathway
Axon guidance pathway
Developmental Biology pathway
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| KEGG | |||||||||||
| INOH | |||||||||||
| PID NCI | |||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||
| NETPATH | |||||||||||
| REACTOME |
Netrin-1 signaling pathway
Developmental Biology pathway
Axon guidance pathway
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| KEGG | |||||||||||
| INOH | |||||||||||
| PID NCI | |||||||||||
| Cross-References | |||||||||||
| SwissProt | Q7TQ33 | ||||||||||
| TrEMBL | |||||||||||
| UniProt Splice Variant | |||||||||||
| Entrez Gene | 68799 | ||||||||||
| UniGene | Mm.293466 Mm.397987 | ||||||||||
| RefSeq | NM_178615 XM_006524865 | ||||||||||
| OMIM | |||||||||||
| CCDS | CCDS37455 | ||||||||||
| HPRD | |||||||||||
| IMGT | |||||||||||
| MGI ID | MGI:1916049 | ||||||||||
| MGI Symbol | Rgmb | ||||||||||
| EMBL | AJ557514 AK035713 AK080819 BC096024 BC138890 | ||||||||||
| GenPept | AAH96024 AAI38891 BAC29163 BAC38034 CAD89719 | ||||||||||
| RNA Seq Atlas | 68799 | ||||||||||