InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rfx3

Summary

InnateDB Protein

IDBP-621015.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rfx3

Protein Name

regulatory factor X, 3 (influences HLA class II expression)

Synonyms

C230093O12Rik; MRFX3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000133461

InnateDB Gene

IDBG-156327 (Rfx3)

Protein Structure

UniProt Annotation

Function

Transcription factor required for ciliogenesis and islet cell differentiation during endocrine pancreas development. Essential for the differentiation of nodal monocilia and left- right asymmetry specification during embryogenesis. Required for the biogenesis of motile cilia by governing growth and beating efficiency of motile cells. Also required for ciliated ependymal cell differentiation. Together with RFX6, participates in the differentiation of 4 of the 5 islet cell types during endocrine pancreas development, with the exception of pancreatic PP (polypeptide-producing) cells. Regulates transcription by forming a heterodimer with another RFX protein and binding to the X-box in the promoter of target genes. Regulates the expression of genes involved in ciliary assembly (DYNC2LI1, FOXJ1 and BBS4) and genes involved in ciliary motility (DNAH11, DNAH9 and DNAH5). Represses transcription of MAP1A in non-neuronal cells but not in neuronal cells. {ECO:0000269PubMed:15121860, ECO:0000269PubMed:16930429, ECO:0000269PubMed:17229940, ECO:0000269PubMed:19671664}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00858, ECO:0000269PubMed:19671664}.

Disease Associations

Tissue Specificity

Expressed in ciliated cells of the node and in the ciliated ependymal cells of the subcommissural organ (SCO), choroid plexuses (CP) and ventricular walls during embryonic and postnatal development. Expressed in developing and mature pancreatic endocrine cells during embryogenesis and in adults (at protein level). {ECO:0000269PubMed:15121860, ECO:0000269PubMed:16930429, ECO:0000269PubMed:17229940}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007368	determination of left/right symmetry
GO:0031018	endocrine pancreas development
GO:0042384	cilium assembly
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048469	cell maturation
GO:0050796	regulation of insulin secretion
GO:0060285	cilium-dependent cell motility
GO:0060287	epithelial cilium movement involved in determination of left/right asymmetry
GO:0072560	type B pancreatic cell maturation
GO:2000078	positive regulation of type B pancreatic cell development