Version 5.4
Mus musculus Gene: Rfx3
Summary
InnateDB Gene IDBG-156327.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rfx3
Gene Name regulatory factor X, 3 (influences HLA class II expression)
Synonyms C230093O12Rik; MRFX3
Species Mus musculus
Ensembl Gene ENSMUSG00000040929
Encoded Proteins
IDBP-156329
regulatory factor X, 3 (influences HLA class II expression)
IDBP-621015
regulatory factor X, 3 (influences HLA class II expression)
IDBP-621020
regulatory factor X, 3 (influences HLA class II expression)
IDBP-621021
regulatory factor X, 3 (influences HLA class II expression)
IDBP-621022
regulatory factor X, 3 (influences HLA class II expression)
IDBP-621024
regulatory factor X, 3 (influences HLA class II expression)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000080298:
This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X2, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with other RFX family members. Two transcript variants encoding different isoforms have been described for this gene, and at least one of the variants utilizes alternative polyadenylation signals. [provided by RefSeq, Jul 2008]
This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X2, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with other RFX family members. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:27761721-28011166
Strand Reverse strand
Band C1
Transcripts
ENSMUST00000046898 ENSMUSP00000038760
ENSMUST00000174850 ENSMUSP00000133461
ENSMUST00000172498
ENSMUST00000172907 ENSMUSP00000134141
ENSMUST00000173863 ENSMUSP00000133367
ENSMUST00000173161
ENSMUST00000174420 ENSMUSP00000134700
ENSMUST00000165566 ENSMUSP00000126313
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0044212 transcription regulatory region DNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007368 determination of left/right symmetry
GO:0031018 endocrine pancreas development
GO:0042384 cilium assembly
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048469 cell maturation
GO:0050796 regulation of insulin secretion
GO:0060285 cilium-dependent cell motility
GO:0060287 epithelial cilium movement involved in determination of left/right asymmetry
GO:0072560 type B pancreatic cell maturation
GO:2000078 positive regulation of type B pancreatic cell development
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005667 transcription factor complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000080298
View Gene Order
ENSBTAG00000000819
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.313321 Mm.394476
RefSeq NM_001166414 NM_011265 XM_006526778 XM_006526779 XM_006526780 XM_006526781 XM_006526782 XM_006526783 XM_006526784 XM_006526785
OMIM
CCDS CCDS29725
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca