InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Synj2bp

Summary

InnateDB Protein

IDBP-621054.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Synj2bp

Protein Name

synaptojanin 2 binding protein

Synonyms

AA409442; ActRIP4; ARIP2; ARIP2a; D12Wsu118e; OMP25;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000130691

InnateDB Gene

IDBG-605394 (Synj2bp)

Protein Structure

UniProt Annotation

Function

Isoform 1 regulates endocytosis of activin type 2 receptor kinases through the Ral/RALBP1-dependent pathway and may be involved in suppression of activin-induced signal transduction. Isoform 2 and isoform 3 show a stimulatory affect on activin- induced signal transduction and enhance activin type 2 expression at the cell surface. {ECO:0000269PubMed:11882656, ECO:0000269PubMed:16648306}.

Subcellular Localization

Mitochondrion outer membrane {ECO:0000250UniProtKB:Q9WVJ4}; Single-pass type IV membrane protein {ECO:0000250UniProtKB:Q9WVJ4}; Cytoplasmic side {ECO:0000250UniProtKB:Q9WVJ4}. Cytoplasm, perinuclear region {ECO:0000269PubMed:11882656}.

Disease Associations

Tissue Specificity

Isoform 1 and isoform 2 are widely expressed, notably in brain, heart, lung, liver, kidney, skeletal muscle, ovary and testis. Isoform 3 is detected only in heart, spleen and testis. {ECO:0000269PubMed:11882656, ECO:0000269PubMed:16648306}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0070699	type II activin receptor binding

Biological Process

GO:0002092	positive regulation of receptor internalization
GO:0006897	endocytosis
GO:0032926	negative regulation of activin receptor signaling pathway
GO:0032927	positive regulation of activin receptor signaling pathway
GO:0048312	intracellular distribution of mitochondria
GO:2000010	positive regulation of protein localization to cell surface