Mus musculus Protein: Map3k8
Summary
InnateDB Protein IDBP-621137.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Map3k8
Protein Name mitogen-activated protein kinase kinase kinase 8
Synonyms c-COT; Cot; Cot/Tpl2; Est; Estf; Tpl-2; Tpl2;
Species Mus musculus
Ensembl Protein ENSMUSP00000133469
InnateDB Gene IDBG-127807 (Map3k8)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 35 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 35 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004709 MAP kinase kinase kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0000165 MAPK cascade
GO:0000186 activation of MAPKK activity
GO:0035556 intracellular signal transduction
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:1346878
InterPro IPR011009 Protein kinase-like domain
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL G3UWY2
UniProt Splice Variant
Entrez Gene 26410
UniGene Mm.416346
RefSeq
MGI ID
MGI Symbol Map3k8
OMIM
CCDS
HPRD
IMGT
EMBL AC138768
GenPept