InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Htr7

Summary

InnateDB Protein

IDBP-621223.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Htr7

Protein Name

5-hydroxytryptamine (serotonin) receptor 7

Synonyms

5-HT7;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000126847

InnateDB Gene

IDBG-160393 (Htr7)

Protein Structure

UniProt Annotation

Function

This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004993	serotonin receptor activity

Biological Process

GO:0006939	smooth muscle contraction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007210	serotonin receptor signaling pathway
GO:0007268	synaptic transmission
GO:0007623	circadian rhythm
GO:0042310	vasoconstriction

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:99841

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR001069 5-Hydroxytryptamine 7 receptor
IPR001671 Melanocortin/ACTH receptor
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR00237
PR00652
PR00534

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P32304