InnateDB Protein
|
IDBP-621255.3
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
Pdlim5
|
Protein Name
|
PDZ and LIM domain 5
|
Synonyms
|
1110001A05Rik; AI987914; C87059; Enh; Enh1; Enh2; Enh3; LIM;
|
Species
|
Mus musculus
|
Ensembl Protein
|
ENSMUSP00000132647
|
InnateDB Gene
|
IDBG-197000 (Pdlim5)
|
Protein Structure
|
|
Function |
May play an important role in the heart development by scaffolding PKC to the Z-disk region. Isoform 2 and isoform 3 may negatively modulate the scaffolding activity of isoform 1. May play a role in the regulation of cardiomyocyte expansion. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May restrain postsynaptic growth of excitatory synapses (By similarity). {ECO:0000250}.
|
Subcellular Localization |
Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Cell junction, synapse, synaptosome {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Detected both at presynaptic and postsynaptic sites. {ECO:0000250}.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated |
Total |
8
[view]
|
Protein-Protein |
8
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
11 [view]
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
MGI:1927489
|
InterPro |
IPR001478
PDZ domain
|
PFAM |
PF00595
PF13180
|
PRINTS |
|
PIRSF |
|
SMART |
SM00228
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q8CI51
|
PhosphoSite |
PhosphoSite-Q8CI51
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
56376
|
UniGene |
Mm.413081
|
RefSeq |
NP_062783
|
MGI ID |
1WF7
|
MGI Symbol |
Pdlim5
|
OMIM |
|
CCDS |
CCDS17876
|
HPRD |
|
IMGT |
|
EMBL |
AB016586
AB016587
AB016588
AK147999
BC037476
|
GenPept |
AAH37476
BAA88827
BAA88828
BAA88829
BAE28279
|
|
|