Version 5.4
Mus musculus Gene: Pdlim5
Summary
InnateDB Gene IDBG-197000.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pdlim5
Gene Name PDZ and LIM domain 5
Synonyms 1110001A05Rik; AI987914; C87059; Enh; Enh1; Enh2; Enh3; LIM
Species Mus musculus
Ensembl Gene ENSMUSG00000028273
Encoded Proteins
IDBP-197002
PDZ and LIM domain 5
IDBP-197004
PDZ and LIM domain 5
IDBP-197008
PDZ and LIM domain 5
IDBP-621255
PDZ and LIM domain 5
IDBP-621256
PDZ and LIM domain 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163110:
This gene encodes a member of a family of proteins that possess a 100-amino acid PDZ domain at the N terminus and one to three LIM domains at the C-terminus. This family member functions as a scaffold protein that tethers protein kinases to the Z-disk in striated muscles. It is thought to function in cardiomyocyte expansion and in restraining postsynaptic growth of excitatory synapses. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:142239586-142395696
Strand Reverse strand
Band H1
Transcripts
ENSMUST00000029941 ENSMUSP00000029941
ENSMUST00000090134 ENSMUSP00000087595
ENSMUST00000058626 ENSMUSP00000059267
ENSMUST00000168967 ENSMUSP00000132647
ENSMUST00000170361 ENSMUSP00000128752
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005080 protein kinase C binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0042805 actinin binding
GO:0047485 protein N-terminus binding
Biological Process
GO:0051963 regulation of synapse assembly
GO:0061001 regulation of dendritic spine morphogenesis
Cellular Component
GO:0005829 cytosol
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0030018 Z disc
GO:0030054 cell junction
GO:0043005 neuron projection
GO:0045211 postsynaptic membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000163110
View Gene Order
ENSBTAG00000012818
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_24
TSLP pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL D9J303 E9Q8P5
UniProt Splice Variant
Entrez Gene 56376
UniGene Mm.405526 Mm.409710 Mm.413081
RefSeq NM_001190857 NM_022554 XM_006501750 XM_006501751 NM_001190853 NM_001190854 NM_001190855 NM_001190856 NM_019808 NM_019809 XM_006501748
OMIM
CCDS CCDS38656 CCDS17875 CCDS17876 CCDS57258
HPRD
IMGT
MGI ID MGI:1927489
MGI Symbol Pdlim5
EMBL AC139128 AC158581 HM369798
GenPept ADI88508
RNA Seq Atlas 56376

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca