InnateDB Protein
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IDBP-621373.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Pus1
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Protein Name
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pseudouridine synthase 1
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Synonyms
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A730013B20Rik; MPUS1; mPus1p;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000130814
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InnateDB Gene
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IDBG-190350 (Pus1)
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Protein Structure
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Function |
Converts specific uridines to PSI in a number of tRNA substrates. Acts on positions 27/28 in the anticodon stem and also positions 34 and 36 in the anticodon of an intron containing tRNA. Involved in regulation of nuclear receptor activity possibly through pseudouridylation of SRA1 RNA. Isoforms 3 and 4 do not form pseudouridine when expressed in vitro. {ECO:0000269PubMed:10094309, ECO:0000269PubMed:11085940, ECO:0000269PubMed:15327771}.
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Subcellular Localization |
Isoform 1: Mitochondrion {ECO:0000250}.Isoform 2: Nucleus {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
1
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
5 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1929237
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InterPro |
IPR001406
Pseudouridine synthase I, TruA
IPR020097
Pseudouridine synthase I, TruA, alpha/beta domain
IPR020103
Pseudouridine synthase, catalytic domain
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PFAM |
PF01416
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PRINTS |
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PIRSF |
PIRSF001430
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9WU56
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PhosphoSite |
PhosphoSite-Q9WU56
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TrEMBL |
D3YWU8
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UniProt Splice Variant |
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Entrez Gene |
56361
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UniGene |
Mm.23528
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RefSeq |
NP_001020733
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MGI ID |
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MGI Symbol |
Pus1
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OMIM |
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CCDS |
CCDS39212
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HPRD |
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IMGT |
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EMBL |
AB041563
AC161348
AF116237
AF269250
AK089258
AK138570
BC021446
BC034359
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GenPept |
AAD21041
AAG35307
AAG35308
AAH21446
AAH34359
BAA95047
BAC40817
BAE23701
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