InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Apobec3

Summary

InnateDB Protein

IDBP-621419.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Apobec3

Protein Name

apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3

Synonyms

Arp3; BC003314; Cem15; Rfv3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000132391

InnateDB Gene

IDBG-163088 (Apobec3)

Protein Structure

UniProt Annotation

Function

DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA. Exhibits antiviral activity against HIV-1, simian immunodeficiency viruses (SIVs), mouse mammary tumor virus (MMTV) and friend murine leukemia virus (FrMLV) and may inhibit the mobility of LTR retrotransposons. {ECO:0000269PubMed:16378963, ECO:0000269PubMed:16527742, ECO:0000269PubMed:17259974, ECO:0000269PubMed:18786991}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:16527742}.

Disease Associations

Tissue Specificity

Expressed in spleen, node and lung. {ECO:0000269PubMed:12859895}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004126	cytidine deaminase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines

Biological Process

GO:0002244	hematopoietic progenitor cell differentiation
GO:0008152	metabolic process
GO:0009972	cytidine deamination
GO:0010529	negative regulation of transposition
GO:0045071	negative regulation of viral genome replication
GO:0045087	innate immune response
GO:0045869	negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
GO:0051607	defense response to virus
GO:0070383	DNA cytosine deamination