InnateDB Protein
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IDBP-621462.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Il1rap
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Protein Name
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interleukin 1 receptor accessory protein
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Synonyms
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6430709H04Rik; AI255955; AV239853; IL-1RAcP;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000134202
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InnateDB Gene
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IDBG-150439 (Il1rap)
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Protein Structure
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Function |
Coreceptor with IL1R1. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Secreted forms (isoforms 2 and 3) associate with secreted ligand-bound IL1R2 and increase the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors (By similarity). {ECO:0000250}.
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Subcellular Localization |
Isoform 1: Cell membrane; Single-pass type I membrane protein.Isoform 2: Secreted.
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Disease Associations |
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Tissue Specificity |
Detected in lung, brain, spleen, thymus and liver. {ECO:0000269PubMed:7775431}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.
Experimentally validated |
Total |
12
[view]
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Protein-Protein |
12
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
25 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:104975
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InterPro |
IPR003599
Immunoglobulin subtype
IPR004074
Interleukin-1 receptor type I/II
IPR007110
Immunoglobulin-like domain
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PFAM |
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PRINTS |
PR01536
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PIRSF |
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SMART |
SM00409
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TIGRFAMs |
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Modification |
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SwissProt |
Q61730
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PhosphoSite |
PhosphoSite-Q61730
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TrEMBL |
Q3UEL3
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UniProt Splice Variant |
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Entrez Gene |
16180
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UniGene |
Mm.405160
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RefSeq |
NP_598864
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MGI ID |
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MGI Symbol |
Il1rap
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OMIM |
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CCDS |
CCDS57023
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HPRD |
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IMGT |
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EMBL |
AK039582
AK045686
AK149467
BC021159
X85999
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GenPept |
AAH21159
BAC30392
BAC32457
BAE28898
CAA59991
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