InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Il1rap

Summary

InnateDB Gene

IDBG-150439.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Il1rap

Gene Name

interleukin 1 receptor accessory protein

Synonyms

6430709H04Rik; AI255955; AV239853; IL-1RAcP

Species

Mus musculus

Ensembl Gene

ENSMUSG00000022514

Encoded Proteins

IDBP-150441

interleukin 1 receptor accessory protein

IDBP-150443

interleukin 1 receptor accessory protein

IDBP-621461

interleukin 1 receptor accessory protein

IDBP-621462

interleukin 1 receptor accessory protein

IDBP-621465

interleukin 1 receptor accessory protein

IDBP-621466

interleukin 1 receptor accessory protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 22426547

Il1rap is recruited to the Il1b::Il1r1 ligand-receptor complex to initiate the Il1b signalling cascade. (Demonstrated in human)

InnateDB Annotation from Orthologs

Summary

PMID 22426547

[Homo sapiens] IL1RAP is recruited to the IL1B::IL1R1 ligand-receptor complex to initiate the IL1B signalling cascade.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000196083:
Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. This gene encodes the interleukin 1 receptor accessory protein. The protein is a necessary part of the interleukin 1 receptor complex which initiates signalling events that result in the activation of interleukin 1-responsive genes. Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble. The ratio of soluble to membrane-bound forms increases during acute-phase induction or stress. [provided by RefSeq, Nov 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:26581704-26730117

Strand

Forward strand

Band

Transcripts

ENSMUST00000096129	ENSMUSP00000093843
ENSMUST00000023156	ENSMUSP00000023156
ENSMUST00000166294	ENSMUSP00000128100
ENSMUST00000174202	ENSMUSP00000134202
ENSMUST00000174171	ENSMUSP00000133904
ENSMUST00000173136	ENSMUSP00000133294
ENSMUST00000174644

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	25 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0004908	interleukin-1 receptor activity
GO:0005515	protein binding

Biological Process

GO:0007165	signal transduction
GO:0019221	cytokine-mediated signaling pathway
GO:0042094	interleukin-2 biosynthetic process
GO:0045087	innate immune response (InnateDB)