InnateDB Protein
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IDBP-621494.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Lcor
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Protein Name
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ligand dependent nuclear receptor corepressor
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000126441
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InnateDB Gene
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IDBG-165927 (Lcor)
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Protein Structure
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Function |
Repressor of ligand-dependent transcription activation by various nuclear repressors. Repressor of ligand-dependent transcription activation by ESR1, ESR2, NR3C1, PGR, RARA, RARB, RARG, RXRA and VDR (By similarity). May act as transcription activator that binds DNA elements with the sequence 5'- CCCTATCGATCGATCTCTACCT-3'. {ECO:0000250, ECO:0000269PubMed:12560079}.
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Subcellular Localization |
Nucleus {ECO:0000255PROSITE- ProRule:PRU00320}.
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Disease Associations |
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Tissue Specificity |
Detected in heart and kidney. {ECO:0000269PubMed:12560079}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
|
Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
9 [view]
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Molecular Function |
Accession |
GO Term |
GO:0003677
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DNA binding
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GO:0003700
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sequence-specific DNA binding transcription factor activity
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GO:0008134
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transcription factor binding
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Biological Process |
GO:0000122
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negative regulation of transcription from RNA polymerase II promoter
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GO:0006357
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regulation of transcription from RNA polymerase II promoter
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GO:0006366
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transcription from RNA polymerase II promoter
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Cellular Component |
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PDB ID |
MGI:2443930
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InterPro |
IPR007889
DNA binding HTH domain, Psq-type
IPR009057
Homeodomain-like
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PFAM |
PF04218
PF05225
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q6ZPI3
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PhosphoSite |
PhosphoSite-Q6ZPI3
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TrEMBL |
A4FTY7
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UniProt Splice Variant |
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Entrez Gene |
212391
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UniGene |
Mm.422910
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RefSeq |
NP_742166
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MGI ID |
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MGI Symbol |
Lcor
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OMIM |
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CCDS |
CCDS29810
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HPRD |
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IMGT |
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EMBL |
AB076079
AK041090
AK041621
AK129442
AK155007
BC050068
BC090652
BC099938
CH466534
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GenPept |
AAH50068
AAH90652
AAH99938
BAC20955
BAC30816
BAC31007
BAC98252
BAE32988
EDL41857
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