Version 5.4
Homo sapiens Protein: MLXIP
Summary
InnateDB Protein IDBP-62152.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MLXIP
Protein Name MLX interacting protein
Synonyms bHLHe36; MIR; MONDOA;
Species Homo sapiens
Ensembl Protein ENSP00000312834
InnateDB Gene IDBG-62150 (MLXIP)
Protein Structure
UniProt Annotation
Function Binds DNA as a heterodimer with MLX and activates transcription. Binds to the canonical E box sequence 5'-CACGTG-3'. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation. {ECO:0000250UniProtKB:Q2VPU4, ECO:0000269PubMed:12446771, ECO:0000269PubMed:16782875}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:12446771, ECO:0000269PubMed:16782875}. Nucleus {ECO:0000255PROSITE- ProRule:PRU00981, ECO:0000269PubMed:12446771, ECO:0000269PubMed:16782875}. Mitochondrion outer membrane {ECO:0000269PubMed:12446771, ECO:0000269PubMed:16782875}. Note=Predominantly cytoplasmic but shuttles between cytoplasm and nucleus when associated with MLX. Also associates with the outer mitochondrial membrane and may shuttle between the outer mitochondrial membrane and the nucleus. {ECO:0000250UniProtKB:Q2VPU4, ECO:0000269PubMed:12446771, ECO:0000269PubMed:16782875}.
Disease Associations
Tissue Specificity Widely expressed in adult tissues. Most abundant in skeletal muscle. {ECO:0000269PubMed:11073985}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0046983 protein dimerization activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006913 nucleocytoplasmic transport
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005741 mitochondrial outer membrane
Protein Structure and Domains
PDB ID
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
PFAM PF00010
PRINTS
PIRSF
SMART SM00353
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9HAP2
PhosphoSite PhosphoSite-Q9HAP2
TrEMBL F5H321
UniProt Splice Variant
Entrez Gene 22877
UniGene Hs.731847
RefSeq NP_055753
HUGO HGNC:17055
OMIM 608090
CCDS CCDS73540
HPRD 10478
IMGT
EMBL AB020674 AC048338 AC130894 AC156455 AC190384 AC205581 AF245480 AF245481 AF312918 BC017656 BC028309 BC039704 BC151841
GenPept AAG34121 AAH17656 AAH28309 AAH39704 AAI51842 AAL55689 AAL55690 BAA74890

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca