InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Kifc3

Summary

InnateDB Protein

IDBP-621620.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Kifc3

Protein Name

kinesin family member C3

Synonyms

AI325457; BB123200;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000127427

InnateDB Gene

IDBG-183340 (Kifc3)

Protein Structure

UniProt Annotation

Function

Minus-end microtubule-dependent motor protein. Involved in apically targeted transport. Required for zonula adherens maintenance. {ECO:0000269PubMed:11581287}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000269PubMed:11581287}. Cytoplasmic vesicle membrane {ECO:0000305PubMed:11581287}; Peripheral membrane protein {ECO:0000305PubMed:11581287}. Cell junction, adherens junction {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Note=Localizes along zonula adherens only at mature cell-cell contacts (By similarity). Apical cell membrane. On membrane organelles immediately beneath the apical plasma membrane of renal tubular epithelial cells. Localized in the distal tubules and loops of Henle in the kidney, but not in the proximal tubules or the glomeruli, with stronger staining in the apical area of these epithelial cells. {ECO:0000250}.

Disease Associations

Tissue Specificity

Predominant expression in the kidney, testis and ovary. Also expressed in brain, heart, liver, lung and uterus. {ECO:0000269PubMed:11581287}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003777	microtubule motor activity
GO:0005524	ATP binding
GO:0008017	microtubule binding
GO:0008569	minus-end-directed microtubule motor activity

Biological Process

GO:0007017	microtubule-based process
GO:0007018	microtubule-based movement
GO:0007030	Golgi organization
GO:0008152	metabolic process
GO:0045218	zonula adherens maintenance
GO:0090136	epithelial cell-cell adhesion

Cellular Component

GO:0005794	Golgi apparatus
GO:0005813	centrosome
GO:0005871	kinesin complex
GO:0005874	microtubule
GO:0005915	zonula adherens
GO:0030659	cytoplasmic vesicle membrane