InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slc8a1

Summary

InnateDB Protein

IDBP-621655.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc8a1

Protein Name

solute carrier family 8 (sodium/calcium exchanger), member 1

Synonyms

AI852629; AV344025; D930008O12Rik; Ncx1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000126373

InnateDB Gene

IDBG-200127 (Slc8a1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005432	calcium:sodium antiporter activity
GO:0005515	protein binding

Biological Process

GO:0001892	embryonic placenta development
GO:0002026	regulation of the force of heart contraction
GO:0003007	heart morphogenesis
GO:0006814	sodium ion transport
GO:0006816	calcium ion transport
GO:0007154	cell communication
GO:0009791	post-embryonic development
GO:0035050	embryonic heart tube development
GO:0035725	sodium ion transmembrane transport
GO:0048747	muscle fiber development
GO:0055013	cardiac muscle cell development
GO:0055085	transmembrane transport
GO:0060048	cardiac muscle contraction

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0030315	T-tubule
GO:0042383	sarcolemma

Protein Structure and Domains

PDB ID

MGI:107956

InterPro

IPR001623 DnaJ domain
IPR002987 Sodium/calcium exchanger, isoform 1
IPR003644 Na-Ca exchanger/integrin-beta4
IPR004836 Sodium/calcium exchanger protein
IPR004837 Sodium/calcium exchanger membrane region

PFAM

PF00226
PF03160
PF01699

PRINTS

PR00625
PR01260
PR01259

PIRSF

SMART

SM00271
SM00237

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt