Version 5.4
Mus musculus Gene: Slc8a1
Summary
InnateDB Gene IDBG-200127.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Slc8a1
Gene Name solute carrier family 8 (sodium/calcium exchanger), member 1
Synonyms AI852629; AV344025; D930008O12Rik; Ncx1
Species Mus musculus
Ensembl Gene ENSMUSG00000054640
Encoded Proteins
IDBP-200131
solute carrier family 8 (sodium/calcium exchanger), member 1
IDBP-621655
solute carrier family 8 (sodium/calcium exchanger), member 1
IDBP-621656
solute carrier family 8 (sodium/calcium exchanger), member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000183023:
In cardiac myocytes, Ca(2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca(2+) concentration during contraction is primarily due to release of Ca(2+) from intracellular stores. However, some Ca(2+) also enters the cell through the sarcolemma (plasma membrane). During relaxation, Ca(2+) is sequestered within the intracellular stores. To prevent overloading of intracellular stores, the Ca(2+) that entered across the sarcolemma must be extruded from the cell. The Na(+)-Ca(2+) exchanger is the primary mechanism by which the Ca(2+) is extruded from the cell during relaxation. In the heart, the exchanger may play a key role in digitalis action. The exchanger is the dominant mechanism in returning the cardiac myocyte to its resting state following excitation.[supplied by OMIM, Apr 2004]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:81388691-81649607
Strand Reverse strand
Band E3
Transcripts
ENSMUST00000086538 ENSMUSP00000083725
ENSMUST00000163680 ENSMUSP00000126373
ENSMUST00000163123 ENSMUSP00000132809
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005432 calcium:sodium antiporter activity
GO:0005515 protein binding
GO:0008092 cytoskeletal protein binding
Biological Process
GO:0001892 embryonic placenta development
GO:0002026 regulation of the force of heart contraction
GO:0003007 heart morphogenesis
GO:0006814 sodium ion transport
GO:0006816 calcium ion transport
GO:0007154 cell communication
GO:0009791 post-embryonic development
GO:0034614 cellular response to reactive oxygen species
GO:0035050 embryonic heart tube development
GO:0035725 sodium ion transmembrane transport
GO:0048747 muscle fiber development
GO:0055013 cardiac muscle cell development
GO:0055085 transmembrane transport
GO:0060048 cardiac muscle contraction
GO:0070509 calcium ion import
GO:0071436 sodium ion export
GO:0097369 sodium ion import
GO:1901660 calcium ion export
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0030315 T-tubule
GO:0042383 sarcolemma
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000183023
View Gene Order
ENSBTAG00000013861
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04020
Calcium signaling pathway pathway
mmu04260
Cardiac muscle contraction pathway
mmu05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
mmu05410
Hypertrophic cardiomyopathy (HCM) pathway
mmu05414
Dilated cardiomyopathy pathway
mmu04974
Protein digestion and absorption pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_23765
Reduction of cytosolic Ca++ levels pathway
REACT_23876
Platelet homeostasis pathway
REACT_19320
Sodium/Calcium exchangers pathway
REACT_19397
Transport of inorganic cations/anions and amino acids/oligopeptides pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_23905
Platelet calcium homeostasis pathway
REACT_19118
SLC-mediated transmembrane transport pathway
REACT_604
Hemostasis pathway
KEGG
hsa04020
Calcium signaling pathway pathway
hsa05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
hsa05410
Hypertrophic cardiomyopathy (HCM) pathway
hsa04260
Cardiac muscle contraction pathway
hsa05414
Dilated cardiomyopathy pathway
hsa04974
Protein digestion and absorption pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL G3X9J1 Q8R505 Q91ZJ7 Q91ZQ6 Q9ET70 Q9ET71 Q9ET73
UniProt Splice Variant
Entrez Gene 20541
UniGene Mm.265834
RefSeq NM_001286684 NM_011406 XM_006523932 XM_006523933 XM_006523934 XM_006523935 XM_006523936 XM_006523937 NM_001112798 XM_006523938 XM_006523939 XM_006523940
OMIM
CCDS CCDS37706 CCDS50191
HPRD
IMGT
MGI ID MGI:107956
MGI Symbol Slc8a1
EMBL AB030891 AB080744 AC122399 AC131656 AC175058 AF409089 AF423306 CH466537
GenPept AAK98607 AAL18847 BAB08170 BAB08175 BAB08176 BAB85833 EDL38542
RNA Seq Atlas 20541

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca