InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PPFIA1

Summary

InnateDB Protein

IDBP-62177.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PPFIA1

Protein Name

protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1

Synonyms

LIP.1; LIP1; LIPRIN;

Species

Homo sapiens

Ensembl Protein

ENSP00000374198

InnateDB Gene

IDBG-62169 (PPFIA1)

Protein Structure

UniProt Annotation

Function

May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. {ECO:0000269PubMed:7796809}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:7796809}. Note=Colocalizes with PTPRF at the ends of focal adhesions most proximal to the cell nucleus.

Disease Associations

Tissue Specificity

Ubiquitous. {ECO:0000269PubMed:7796809, ECO:0000269PubMed:9624153}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 50 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	50 [view]
Protein-Protein	49 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005515	protein binding

Biological Process

GO:0007160	cell-matrix adhesion
GO:0007165	signal transduction
GO:0051497	negative regulation of stress fiber assembly
GO:0090005	negative regulation of establishment of protein localization to plasma membrane

Cellular Component

GO:0005737	cytoplasm
GO:0005925	focal adhesion

Protein Structure and Domains

PDB ID

InterPro

IPR001660 Sterile alpha motif domain
IPR011510 Sterile alpha motif, type 2
IPR013761 Sterile alpha motif/pointed domain
IPR021129 Sterile alpha motif, type 1

PFAM

PF07647
PF00536

PRINTS

PIRSF

SMART

SM00454

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q13136