InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Abcg8

Summary

InnateDB Protein

IDBP-621908.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Abcg8

Protein Name

ATP-binding cassette, sub-family G (WHITE), member 8

Synonyms

1300003C16Rik; AI114946; sterolin-2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000126675

InnateDB Gene

IDBG-200717 (Abcg8)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005524	ATP binding
GO:0016887	ATPase activity
GO:0017127	cholesterol transporter activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006200	ATP catabolic process
GO:0007584	response to nutrient
GO:0007588	excretion
GO:0010949	negative regulation of intestinal phytosterol absorption
GO:0015914	phospholipid transport
GO:0015918	sterol transport
GO:0033344	cholesterol efflux
GO:0042493	response to drug
GO:0042632	cholesterol homeostasis
GO:0045796	negative regulation of intestinal cholesterol absorption
GO:0055092	sterol homeostasis

Cellular Component

GO:0016020	membrane
GO:0016324	apical plasma membrane

Protein Structure and Domains

PDB ID

MGI:1914720

InterPro

IPR003439 ABC transporter-like
IPR013525 ABC-2 type transporter
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00005
PF01061

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

Q923R9

UniProt Splice Variant

Entrez Gene

67470

UniGene

Mm.26581

RefSeq

MGI ID

MGI Symbol

Abcg8

OMIM

CCDS

HPRD

IMGT

EMBL

AC165360 AF404108 AY196216 BC138484 BC145293

GenPept

AAI38485 AAI45294 AAK85391 AAO45096