InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: MOAP1

Summary

InnateDB Protein

IDBP-622071.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MOAP1

Protein Name

modulator of apoptosis 1

Synonyms

AA987038; Map-1; Pnma4;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000133459

InnateDB Gene

IDBG-702743 (MOAP1)

Protein Structure

UniProt Annotation

Function

Required for death receptor-dependent apoptosis. When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Widely expressed, including in the brain. High expression levels in testis. {ECO:0000269PubMed:19366867}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0031625	ubiquitin protein ligase binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0001844	protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0030262	apoptotic nuclear changes
GO:0043065	positive regulation of apoptotic process
GO:0090200	positive regulation of release of cytochrome c from mitochondria
GO:0097190	apoptotic signaling pathway
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand