Version 5.4
Mus musculus Gene: MOAP1
Summary
InnateDB Gene IDBG-702743.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MOAP1
Gene Name Modulator of apoptosis 1
Synonyms AA987038; Map-1; Pnma4
Species Mus musculus
Ensembl Gene ENSMUSG00000096458
Encoded Proteins
IDBP-622071
modulator of apoptosis 1
IDBP-711275
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000165943:
The protein encoded by this gene was identified by its interaction with apoptosis regulator BAX protein. This protein contains a Bcl-2 homology 3 (BH3)-like motif, which is required for the association with BAX. When overexpressed, this gene has been shown to mediate caspase-dependent apoptosis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:102742230-102743661
Strand Reverse strand
Band E
Transcripts
ENSMUST00000173760 ENSMUSP00000133459
ENSMUST00000178384 ENSMUSP00000137010
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0031625 ubiquitin protein ligase binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0001844 protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0030262 apoptotic nuclear changes
GO:0043065 positive regulation of apoptotic process
GO:0090200 positive regulation of release of cytochrome c from mitochondria
GO:0097190 apoptotic signaling pathway
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005829 cytosol
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000165943
View Gene Order
Cross-References
SwissProt Q9ERH6
TrEMBL
UniProt Splice Variant
Entrez Gene 64113
UniGene Mm.489678
RefSeq NM_001142937 NM_022323
OMIM
CCDS CCDS26122
HPRD
IMGT
MGI ID MGI:1915555
MGI Symbol Moap1
EMBL AF305551 AK019599 BC014715 BC055374
GenPept AAG31787 AAH14715 AAH55374 BAB31810
RNA Seq Atlas 64113

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca