InnateDB Protein
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IDBP-622150.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Crx
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Protein Name
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cone-rod homeobox containing gene
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Synonyms
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Crx1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000134400
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InnateDB Gene
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IDBG-145514 (Crx)
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Protein Structure
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Function |
Transcription factor that binds and transactivates the sequence 5'-TAATC[CA]-3' which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, such as NRL, RORB and RAX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors. {ECO:0000269PubMed:16574740}.
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Subcellular Localization |
Nucleus {ECO:0000255PROSITE- ProRule:PRU00108, ECO:0000269PubMed:16574740}.
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Disease Associations |
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Tissue Specificity |
Retina. {ECO:0000269PubMed:16574740}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0000977
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RNA polymerase II regulatory region sequence-specific DNA binding
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GO:0000978
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RNA polymerase II core promoter proximal region sequence-specific DNA binding
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GO:0001077
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RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
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GO:0003677
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DNA binding
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GO:0003682
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chromatin binding
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GO:0003700
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sequence-specific DNA binding transcription factor activity
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GO:0005515
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protein binding
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GO:0035257
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nuclear hormone receptor binding
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GO:0043522
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leucine zipper domain binding
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GO:0043565
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sequence-specific DNA binding
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1194883
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InterPro |
IPR001356
Homeobox domain
IPR009057
Homeodomain-like
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PFAM |
PF00046
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PRINTS |
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PIRSF |
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SMART |
SM00389
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TIGRFAMs |
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Modification |
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SwissProt |
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PhosphoSite |
PhosphoSite-
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TrEMBL |
Q543C9
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UniProt Splice Variant |
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Entrez Gene |
12951
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UniGene |
Mm.441911
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RefSeq |
NP_001106801
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MGI ID |
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MGI Symbol |
Crx
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OMIM |
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CCDS |
CCDS52035
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HPRD |
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IMGT |
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EMBL |
AC148990
AK053533
AK139691
BC016502
CH466654
U77615
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GenPept |
AAB88585
AAH16502
BAC35418
BAE24107
EDL42122
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