InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cdh1

Summary

InnateDB Protein

IDBP-622198.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cdh1

Protein Name

cadherin 1

Synonyms

AA960649; E-cad; Ecad; L-CAM; Um; UVO;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000132112

InnateDB Gene

IDBG-190074 (Cdh1)

Protein Structure

UniProt Annotation

Function

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7 (By similarity). {ECO:0000250}.E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production (By similarity). {ECO:0000250}.

Subcellular Localization

Cell junction. Cell membrane; Single-pass type I membrane protein. Endosome {ECO:0000250}. Golgi apparatus, trans-Golgi network {ECO:0000250}. Note=Colocalizes with DLGAP5 at sites of cell-cell contact in intestinal epithelial cells. Anchored to actin microfilaments through association with alpha-, beta- and gamma-catenin. Sequential proteolysis induced by apoptosis or calcium influx, results in translocation from sites of cell-cell contact to the cytoplasm. Colocalizes with RAB11A endosomes during its transport from the Golgi apparatus to the plasma membrane (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Non-neural epithelial tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.
They are also associated with 128 interaction(s) predicted by orthology.

Experimentally validated
Total	45 [view]
Protein-Protein	36 [view]
Protein-DNA	9 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	128 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0019903	protein phosphatase binding
GO:0019904	protein domain specific binding
GO:0030506	ankyrin binding
GO:0032794	GTPase activating protein binding
GO:0045295	gamma-catenin binding

Biological Process

GO:0001701	in utero embryonic development
GO:0001829	trophectodermal cell differentiation
GO:0003382	epithelial cell morphogenesis
GO:0007156	homophilic cell adhesion
GO:0007416	synapse assembly
GO:0007605	sensory perception of sound
GO:0009636	response to toxic substance
GO:0016337	single organismal cell-cell adhesion
GO:0016339	calcium-dependent cell-cell adhesion
GO:0019538	protein metabolic process
GO:0021983	pituitary gland development
GO:0022408	negative regulation of cell-cell adhesion
GO:0031175	neuron projection development
GO:0032880	regulation of protein localization
GO:0033561	regulation of water loss via skin
GO:0042493	response to drug
GO:0042993	positive regulation of transcription factor import into nucleus
GO:0043281	regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045893	positive regulation of transcription, DNA-templated
GO:0050680	negative regulation of epithelial cell proliferation
GO:0051260	protein homooligomerization
GO:0060576	intestinal epithelial cell development
GO:0060662	salivary gland cavitation
GO:0060693	regulation of branching involved in salivary gland morphogenesis
GO:0070830	tight junction assembly
GO:0071230	cellular response to amino acid stimulus
GO:0071285	cellular response to lithium ion
GO:0071681	cellular response to indole-3-methanol
GO:0090002	establishment of protein localization to plasma membrane
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:0090102	cochlea development
GO:2000008	regulation of protein localization to cell surface
GO:2001222	regulation of neuron migration

Cellular Component

GO:0005737	cytoplasm
GO:0005768	endosome
GO:0005802	trans-Golgi network
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0005912	adherens junction
GO:0005913	cell-cell adherens junction
GO:0005925	focal adhesion
GO:0009898	cytoplasmic side of plasma membrane
GO:0009986	cell surface
GO:0015629	actin cytoskeleton
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016235	aggresome
GO:0016323	basolateral plasma membrane
GO:0016328	lateral plasma membrane
GO:0016342	catenin complex
GO:0030424	axon
GO:0033268	node of Ranvier
GO:0043219	lateral loop
GO:0043220	Schmidt-Lanterman incisure
GO:0043296	apical junction complex
GO:0043679	axon terminus
GO:0045177	apical part of cell
GO:0048471	perinuclear region of cytoplasm
GO:0071944	cell periphery