Version 5.4
Mus musculus Gene: Cdh1
Summary
InnateDB Gene IDBG-190074.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cdh1
Gene Name cadherin 1
Synonyms AA960649; E-cad; Ecad; L-CAM; Um; UVO
Species Mus musculus
Ensembl Gene ENSMUSG00000000303
Encoded Proteins
IDBP-190076
cadherin 1
IDBP-622198
cadherin 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000039068:
This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:106603351-106670246
Strand Forward strand
Band D3
Transcripts
ENSMUST00000000312 ENSMUSP00000000312
ENSMUST00000136580
ENSMUST00000167688 ENSMUSP00000132112
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.
They are also associated with 128 interaction(s) predicted by orthology.
Experimentally validated
Total 45 [view]
Protein-Protein 36 [view]
Protein-DNA 9 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 128 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001948 glycoprotein binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008013 beta-catenin binding
GO:0019903 protein phosphatase binding
GO:0019904 protein domain specific binding
GO:0030506 ankyrin binding
GO:0032794 GTPase activating protein binding
GO:0045295 gamma-catenin binding
Biological Process
GO:0001701 in utero embryonic development
GO:0001829 trophectodermal cell differentiation
GO:0003382 epithelial cell morphogenesis
GO:0007156 homophilic cell adhesion
GO:0007416 synapse assembly
GO:0007605 sensory perception of sound
GO:0009636 response to toxic substance
GO:0010033 response to organic substance
GO:0016337 single organismal cell-cell adhesion
GO:0016339 calcium-dependent cell-cell adhesion
GO:0019538 protein metabolic process
GO:0021983 pituitary gland development
GO:0022408 negative regulation of cell-cell adhesion
GO:0031175 neuron projection development
GO:0032880 regulation of protein localization
GO:0033561 regulation of water loss via skin
GO:0042493 response to drug
GO:0042993 positive regulation of transcription factor import into nucleus
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045893 positive regulation of transcription, DNA-templated
GO:0050680 negative regulation of epithelial cell proliferation
GO:0051260 protein homooligomerization
GO:0060576 intestinal epithelial cell development
GO:0060662 salivary gland cavitation
GO:0060693 regulation of branching involved in salivary gland morphogenesis
GO:0070830 tight junction assembly
GO:0071230 cellular response to amino acid stimulus
GO:0071285 cellular response to lithium ion
GO:0071681 cellular response to indole-3-methanol
GO:0072659 protein localization to plasma membrane
GO:0090002 establishment of protein localization to plasma membrane
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090102 cochlea development
GO:2000008 regulation of protein localization to cell surface
GO:2001222 regulation of neuron migration
Cellular Component
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005802 trans-Golgi network
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0005912 adherens junction
GO:0005913 cell-cell adherens junction
GO:0005925 focal adhesion
GO:0009898 cytoplasmic side of plasma membrane
GO:0009986 cell surface
GO:0015629 actin cytoskeleton
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016235 aggresome
GO:0016323 basolateral plasma membrane
GO:0016328 lateral plasma membrane
GO:0016342 catenin complex
GO:0030424 axon
GO:0033268 node of Ranvier
GO:0043219 lateral loop
GO:0043220 Schmidt-Lanterman incisure
GO:0043296 apical junction complex
GO:0043679 axon terminus
GO:0045177 apical part of cell
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
GO:0071944 cell periphery
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000039068
View Gene Order
ENSBTAG00000015991
Not yet available
Pathways
NETPATH
REACTOME
REACT_258521
Apoptosis pathway
REACT_202937
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
REACT_224460
Apoptotic cleavage of cellular proteins pathway
REACT_212869
Apoptotic cleavage of cell adhesion proteins pathway
REACT_248094
Cell-cell junction organization pathway
REACT_230745
Immune System pathway
REACT_206066
Extracellular matrix organization pathway
REACT_230395
Adherens junctions interactions pathway
REACT_216309
Integrin cell surface interactions pathway
REACT_229531
Adaptive Immune System pathway
REACT_241978
Cell junction organization pathway
REACT_223082
Cell-Cell communication pathway
REACT_207035
Apoptotic execution phase pathway
REACT_199052
Degradation of the extracellular matrix pathway
KEGG
mmu05213
Endometrial cancer pathway
mmu05219
Bladder cancer pathway
mmu04514
Cell adhesion molecules (CAMs) pathway
mmu05216
Thyroid cancer pathway
mmu05218
Melanoma pathway
mmu04520
Adherens junction pathway
mmu05200
Pathways in cancer pathway
mmu05100
Bacterial invasion of epithelial cells pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
NetPath_8
Wnt pathway
REACTOME
REACT_11152
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
REACT_13552
Integrin cell surface interactions pathway
REACT_13579
Apoptotic cleavage of cell adhesion proteins pathway
REACT_107
Apoptotic cleavage of cellular proteins pathway
REACT_995
Apoptotic execution phase pathway
REACT_19195
Adherens junctions interactions pathway
REACT_111155
Cell-Cell communication pathway
REACT_118779
Extracellular matrix organization pathway
REACT_20676
Cell junction organization pathway
REACT_118572
Degradation of the extracellular matrix pathway
REACT_578
Apoptosis pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_19331
Cell-cell junction organization pathway
KEGG
hsa05130
Pathogenic Escherichia coli infection pathway
hsa04514
Cell adhesion molecules (CAMs) pathway
hsa05218
Melanoma pathway
hsa05216
Thyroid cancer pathway
hsa04520
Adherens junction pathway
hsa05213
Endometrial cancer pathway
hsa05219
Bladder cancer pathway
hsa05200
Pathways in cancer pathway
hsa05100
Bacterial invasion of epithelial cells pathway
INOH
PID NCI
ecadherin_1_pathway
E-cadherin signaling events
ecadherin_nascentaj_pathway
E-cadherin signaling in the nascent adherens junction
met_pathway
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
nectin_pathway
Nectin adhesion pathway
a6b1_a6b4_integrin_pathway
a6b1 and a6b4 Integrin signaling
betacatenin_nuc_pathway
Regulation of nuclear beta catenin signaling and target gene transcription
rac1_pathway
RAC1 signaling pathway
fgf_pathway
FGF signaling pathway
cdc42_pathway
CDC42 signaling events
integrin7_pathway
AlphaE beta7 integrin cell surface interactions
ecadherin_stabilization_pathway
Stabilization and expansion of the E-cadherin adherens junction
ecadherin_keratinocyte_pathway
E-cadherin signaling in keratinocytes
arf6_traffickingpathway
Arf6 trafficking events
ajdiss_2pathway
Posttranslational regulation of adherens junction stability and dissassembly
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.35605
RefSeq NM_009864
OMIM
CCDS CCDS22638
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca