InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Zfp57

Summary

InnateDB Protein

IDBP-622222.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Zfp57

Protein Name

zinc finger protein 57

Synonyms

G19; Zfp-57;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000133821

InnateDB Gene

IDBG-182059 (Zfp57)

Protein Structure

UniProt Annotation

Function

Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions. Required for the establishment of maternal methylation imprints at SNRPN locus. Acts as a transcriptional repressor in Schwann cells. Binds to a 5'-TGCCGC- 3' consensus sequence and recognizes the methylated CpG within this element. {ECO:0000269PubMed:15070898, ECO:0000269PubMed:18854139, ECO:0000269PubMed:23059534}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:15070898, ECO:0000269PubMed:18854139, ECO:0000269PubMed:8120052}. Note=Binds various differentially methylated regions (DMR), including the Snrpn DMR.

Disease Associations

Tissue Specificity

Expressed in oocytes and in a subset of adult tissues. Expressed at high levels in testis, and at low levels in cerebellum. Present in sciatic nerve and spinal cord (at protein level). {ECO:0000269PubMed:15070898, ECO:0000269PubMed:8120052}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006349	regulation of gene expression by genetic imprinting
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007422	peripheral nervous system development
GO:0043045	DNA methylation involved in embryo development